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Hadhrat Imām Qāsim ibn Muhammad ibn Abū Bakr as-Siddīq (24-107 AH), radiyAllāhu anhum ajma’īn, was one of the greatest Tābi’īn and one of the great seven jurists of Madinah.

He was grandson of Amīr al-Mu’minīn Abū Bakr as-Siddīq radiyAllāhu anhu, and nephew of Umm al-Mu’mineen Sayyida Āishā Siddīqā raziyAllahu anhā.

He married his cousin Asmā bint Abdur-Rahmān ibn Abū Bakr as-Siddīq radiyAllāhu anhum. They had a daughter named Fātimā, also called Umm Farwā, who was married to Imām Muhammad al-Bāqir bin Imām Zain al-Ābidīn. She was also the mother of Imām Ja’far as-Sādiq, who received the secret of the Naqshbandi way from his grandfather Imām Qāsim.

The next in the Naqshbandī Mujaddidī Tāhirī spiritual golden chain is Imam Ja’far as-Sadiq.
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 "Truly, Allah does not remove Sacred Knowledge by taking it out of servants, but rather by taking back the souls of Islamic scholars [in death], until, when He has not left a single scholar, the people take the ignorant as leaders, who are asked for and who give Islamic legal opinion without knowledge, misguided and misguiding"

(Sahih Bukhari - Fath al-Bari, 1.194, hadith 100) [src: suhba.org]